Kids youthful than 5 years whose dad and mom have been vaccinated towards COVID-19 seemed to be at lowered threat of hospitalization throughout the Delta and Omicron variant waves in France, in accordance with a analysis letter printed yesterday in JAMA Community Open.
Universite de Paris-Cite researchers led the observational examine of 163 preschoolers hospitalized throughout the Delta (39%) and Omicron (58%) intervals from Could 12, 2021, to Feb 14, 2022. In the course of the examine interval, French kids in that age-group weren’t eligible for COVID-19 vaccination, whereas the speed of two-dose vaccination in adults rose from 7% to 92%.
The information have been extracted from the COVID-19 Pediatric Observatory (PANDOR) surveillance examine of hospitalized pediatric COVID-19 sufferers in France.
The estimated hazard ratios for hospitalization amongst kids with vaccinated versus unvaccinated dad and mom have been 0.03 (95% confidence interval [CI], 0.02 to 0.06) throughout the Delta period and 0.21 (95% CI, 0.14 to 0.33) amid Omicron, or 97% and 79% safety, respectively.
“The affiliation between father or mother vaccination and lowered threat of admission for SARS-CoV-2 in kids youthful than 5 years suggests that folks performed a serious position in transmitting SARS-CoV-2 to their younger kids throughout each waves, however the affiliation between safety and vaccination appeared decrease within the Omicron vs Delta interval,” the examine authors wrote. “The Omicron variant has been proven to be extra transmissible, and the vaccine effectiveness towards an infection appears decrease.”
The researchers famous that the examine did not think about whether or not the youngsters had siblings, different potential sources of an infection within the family, environmental modifications, lockdowns, compliance with bodily distancing, dates of parental vaccination, or receipt of booster vaccines, the latter of which constitutes a bias, contemplating the change in vaccine effectiveness over time and throughout variants.
“These outcomes shouldn’t be extrapolated to different variants, such because the predominant [Omicron] variants BA.4 and BA.5,” they wrote. “Nonetheless, these outcomes reinforce suggestions for widespread vaccination of fogeys of younger kids.”